Recently I was setting up a workstation and decided to turn off UAC while finalizing things. Having always worked with UAC on, the absence of confirmation dialogs was brilliant. So whilst I still think UAC is generally a good idea, there are definitely circumstances where it not only can be turned off, but should. If setting up applications and tweaking system settings is something you need to do regularly and you know what you are doing turning UAC off is a great way to save your sanity.
When I turned UAC off for the first time I thought the possible conversation between Maxwell Smart and the Chief on the topic:
The Chief: Max, turning off UAC will mean your processes will execute with your full privileges. You’ll be in constant danger of malware, viruses and trojans.
Max: And loving it.